College Football Picks, Predictions Against The Spread For Every Week 3 Top 25 Game

Group of Five powers are up first on the Week 4 college football odds board when Marshall visits Appalachian State on Thursday evening. The Mountaineers are 7.5-point favorites, according to the latest Week 4 college football spreads from Caesars Sportsbook. There are then four FBS games on Friday, followed by another loaded Saturday slate. Other college football lines of note this weekend include No. 18 Wisconsin (-5.5) against Notre Dame, No. 11 Florida (-20) against Tennessee and No. 7 Texas A&M (-6) against No. 16 Arkansas in the SEC on CBS matchup. 

Derek Mason Vanderbilt © Provided by CBS Sports

Derek Mason Vanderbilt

Is there value on any of those Week 4 college football spreads? And which other lines should you target during the Week 4 college football schedule? Before making any Week 4 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 4 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 4 college football predictions

One of the top college football picks the model is recommending for Week 4: LSU (-2.5) goes on the road and covers at Mississippi State in a noon ET SEC West showdown on Saturday. The Tigers dropped their opener against UCLA on the road. Since that point, LSU has outscored McNeese State and Central Michigan 83-28.

Mississippi State, meanwhile, lost to underdog Memphis last week. The Bulldogs are just 1-2 against the spread thus far, and SportsLine's model shows the Bulldogs struggling on defense as LSU scores 34 points and piles up around 450 yards of total offense in the simulations. LSU covers almost 60 percent of the time, and the over (57) clears in well over 50 percent of simulations. 

Another one of the college football predictions from the model: No. 24 UCLA (-6) covers at Stanford in Pac-12 action at 6 p.m. ET on Saturday. The Bruins had a surprising loss against Fresno State as 11-point favorites in Week 3. That has brought this spread down to a touchdown, and SportsLine's model sees value in a bounce-back spot for Chip Kelly's squad.

UCLA is 2-1 against the spread this season. Stanford took care of business against USC and Vanderbilt, but fell flat in a 24-7 loss against Kansas State earlier in the season. The model predicts that UCLA will run for almost 200 yards in this matchup, helping the Bruins cover 60 percent of the time. The over (58.5) is also a substantial value as that hits almost 60 percent of the time. 

How to make Week 4 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 4 college football schedule, and it's calling for a Top 25 favorite to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past five-plus seasons, and find out.

Week 4 college football odds (via Caesars)

Here are the college football lines for some of Week 4's most notable matchups:

Thursday, Sept. 23

Marshall vs. Appalachian State (-7.5, 57)

Featured Game| Appalachian State Mountaineers vs. Marshall Thundering Herd MoneylineSpreadTotal APLST -300 BET NOW -7.5-105BET NOW o56-110BET NOW MRSHL +240 BET NOW +7.5-115BET NOW u56-110BET NOW

Friday, Sept. 24

MTSU vs. Charlotte (-2.5, 56.5)

Featured Game| Charlotte 49ers vs. Middle Tenn. Blue Raiders MoneylineSpreadTotal CHARLO -130 BET NOW -2.5-110BET NOW o56.5-110BET NOW MTSU +110 BET NOW +2.5-110BET NOW u56.5-110BET NOW

Wake Forest vs. Virginia (-4, 67)

Featured Game| Virginia Cavaliers vs. Wake Forest Demon Deacons MoneylineSpreadTotal UVA -190 BET NOW -4-110BET NOW o67-110BET NOW WAKE +160 BET NOW +4-110BET NOW u67-110BET NOW

Liberty vs. Syracuse (+6, 52.5)

Featured Game| Syracuse Orange vs. Liberty Flames MoneylineSpreadTotal CUSE +190 BET NOW +6-110BET NOW o52.5-110BET NOW LIB -230 BET NOW -6-110BET NOW u52.5-110BET NOW

Fresno State vs. UNLV (+31.5, 58.5)

Featured Game| Fresno State Bulldogs vs. UNLV Rebels MoneylineSpreadTotal FRESNO -15000 BET NOW -31.5-110BET NOW o58.5-110BET NOW UNLV +2500 BET NOW +31.5-110BET NOW u58.5-110BET NOW

Saturday, Sept. 25

Georgia vs. Vanderbilt (+34, 51)

Notre Dame vs. Wisconsin (-5.5, 46.5)

Featured Game| Wisconsin Badgers vs. Notre Dame Fighting Irish MoneylineSpreadTotal WISC -230 BET NOW -5.5-110BET NOW o46.5-110BET NOW ND +190 BET NOW +5.5-110BET NOW u46.5-110BET NOW

UMass vs. Coastal Carolina (-36, 67)

Rutgers vs. Michigan (-18.5, 51.5)

Clemson vs. NC State (+10, 47)

Featured Game| NC State Wolfpack vs. Clemson Tigers MoneylineSpreadTotal NCST +310 BET NOW +10-110BET NOW o47-110BET NOW CLEM -400 BET NOW -10-110BET NOW u47-110BET NOW

Iowa State vs. Baylor (+6.5, 47.5)

Featured Game| Baylor Bears vs. Iowa State Cyclones MoneylineSpreadTotal BAYLOR +200 BET NOW +6.5-110BET NOW o47.5-110BET NOW IOWAST -240 BET NOW -6.5-110BET NOW u47.5-110BET NOW

Colorado State vs. Iowa (-23, 44.5)

Featured Game| Iowa Hawkeyes vs. Colorado State Rams MoneylineSpreadTotal IOWA -2400 BET NOW -23-110BET NOW o44.5-110BET NOW COLOST +1100 BET NOW +23-110BET NOW u44.5-110BET NOW

Texas A&M vs. Arkansas (+5.5, 48)

Featured Game| Arkansas Razorbacks vs. Texas A&M Aggies MoneylineSpreadTotal ARK +180 BET NOW +5.5-110BET NOW o48-110BET NOW TXAM -220 BET NOW -5.5-110BET NOW u48-110BET NOW

Georgia State vs. Auburn (-27, 57)

Featured Game| Arkansas Razorbacks vs. Texas A&M Aggies MoneylineSpreadTotal ARK +180 BET NOW +5.5-110BET NOW o48-110BET NOW TXAM -220 BET NOW -5.5-110BET NOW u48-110BET NOW

UCLA vs. Stanford (+6, 58.5)

Featured Game| Stanford Cardinal vs. UCLA Bruins MoneylineSpreadTotal STNFRD +190 BET NOW +6-110BET NOW o58.5-110BET NOW UCLA -230 BET NOW -6-110BET NOW u58.5-110BET NOW

Nebraska vs. Michigan State (-5, 51.5)

Featured Game| Michigan State Spartans vs. Nebraska Cornhuskers MoneylineSpreadTotal MICHST -200 BET NOW -5-110BET NOW o51.5-110BET NOW NEB +170 BET NOW +5-110BET NOW u51.5-110BET NOW

Kansas State vs. Oklahoma State (-6, 45)

Featured Game| Oklahoma State Cowboys vs. Kansas State Wildcats MoneylineSpreadTotal OKLAST -240 BET NOW -6-110BET NOW o45.5-110BET NOW KSTATE +200 BET NOW +6-110BET NOW u45.5-110BET NOW

North Carolina vs. Georgia Tech (+12, 63)

Featured Game| Georgia Tech Yellow Jackets vs. North Carolina Tar Heels MoneylineSpreadTotal GATECH +350 BET NOW +12-110BET NOW o63-110BET NOW UNC -450 BET NOW -12-110BET NOW u63-110BET NOW

Akron vs. Ohio State (-49, 67.5)

Alabama vs. Southern Mississippi (+45, 57.5)

Oklahoma vs. West Virginia (+16.5, 59)

Featured Game| Oklahoma Sooners vs. West Virginia Mountaineers MoneylineSpreadTotal OKLA -800 BET NOW -16.5-110BET NOW o59-110BET NOW WVU +550 BET NOW +16.5-110BET NOW u59-110BET NOW

USF vs. BYU (-23, 52)

Featured Game| BYU Cougars vs. South Florida Bulls MoneylineSpreadTotal BYU -2400 BET NOW -23-110BET NOW o52-110BET NOW SFLA +1100 BET NOW +23-110BET NOW u52-110BET NOW

Arizona vs. Oregon (-28, 58)

Source : https://www.msn.com/en-us/sports/ncaafb/college-football-odds-lines-picks-bets-predictions-for-week-4-2021-proven-computer-backing-lsu-ucla/ar-AAODLlV

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